Constantin Lapa Selected Research

PSMA I&T

12/2023	First Safety and Efficacy Data with the Radiohybrid 177Lu-rhPSMA-10.1 for the Treatment of Metastatic Prostate Cancer.
12/2023	An Intrapatient Dosimetry Comparison of 177Lu-rhPSMA-10.1 and 177Lu-PSMA-I&T in Patients with Metastatic Castration-Resistant Prostate Cancer.
10/2023	Early biochemical and radiographic response after one cycle of [177Lu]Lu-PSMA I&T radioligand therapy in metastatic castration-resistant prostate cancer patients.
4/2023	177 Lu-rhPSMA-10.1 Induces Tumor Response in a Patient With mCRPC After PSMA-Directed Radioligand Therapy With 177 Lu-PSMA-I&T.
1/2022	Diverse PSMA expression in primary prostate cancer: reason for negative [68Ga]Ga-PSMA PET/CT scans? Immunohistochemical validation in 40 surgical specimens.
2/2020	DNA Damage in Blood Leukocytes of Prostate Cancer Patients Undergoing PET/CT Examinations with [68Ga]Ga-PSMA I&T.

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Constantin Lapa Research Topics

Disease

69	Neoplasms (Cancer) 03/2024 - 09/2012
33	Prostatic Neoplasms (Prostate Cancer) 05/2024 - 06/2015
20	Multiple Myeloma 09/2023 - 09/2014
20	Neuroendocrine Tumors (Neuroendocrine Tumor) 08/2021 - 09/2012
13	Thyroid Neoplasms (Thyroid Cancer) 12/2023 - 09/2012
12	Neoplasm Metastasis (Metastasis) 11/2023 - 02/2016
10	Inflammation (Inflammations) 01/2023 - 09/2012
6	Lymphoma (Lymphomas) 01/2024 - 11/2018
6	Small Cell Lung Carcinoma (Small Cell Lung Cancer) 10/2023 - 02/2016
5	Hematologic Neoplasms (Hematological Malignancy) 01/2023 - 10/2019
5	Glioblastoma (Glioblastoma Multiforme) 03/2022 - 01/2015
5	Parkinsonian Disorders (Parkinsonism) 12/2020 - 01/2015
4	medullary Thyroid cancer 11/2023 - 04/2015
4	Adrenocortical Carcinoma 11/2022 - 03/2016
4	Glioma (Gliomas) 09/2022 - 10/2014
4	Heart Failure 01/2022 - 09/2015
4	Parkinson Disease (Parkinson's Disease) 01/2021 - 01/2015
4	Myocardial Infarction 01/2019 - 09/2015
4	Sarcoidosis (Schaumann Disease) 01/2018 - 09/2015
3	T-Cell Lymphoma (Lymphoma, T Cell) 01/2024 - 01/2023
3	Hepatocellular Carcinoma (Hepatoma) 12/2022 - 06/2016
3	Meningioma (Meningiomas) 09/2022 - 01/2018
3	Carcinoma (Carcinomatosis) 01/2020 - 02/2016
3	Myocarditis (Carditis) 01/2019 - 09/2015
2	Merkel Cell Carcinoma 02/2024 - 04/2014
2	Paraganglioma (Paragangliomas) 01/2023 - 01/2022
2	Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell, Diffuse) 01/2023 - 01/2019
2	Hemorrhage 10/2022 - 10/2021
2	Brain Neoplasms (Brain Tumor) 09/2022 - 12/2019
2	Cholangiocarcinoma 01/2022 - 01/2019
2	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 08/2021 - 04/2020
2	Leukemia 01/2019 - 01/2018
2	Type 2 Diabetes Mellitus (MODY) 12/2018 - 12/2017
2	Hypertension (High Blood Pressure) 09/2013 - 09/2012
1	Gastrointestinal Neoplasms (Gastrointestinal Cancer) 01/2024
1	Chronic Renal Insufficiency 10/2023

Drug/Important Bio-Agent (IBA)

31	Chemokine ReceptorsIBA 01/2024 - 04/2015
25	68Ga-pentixaforIBA 01/2024 - 12/2015
23	AntigensIBA 12/2023 - 06/2015
20	Somatostatin Receptors (Somatostatin Receptor)IBA 12/2023 - 09/2012
19	Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)FDA Link 11/2021 - 08/2012
14	Radioisotopes (Radionuclides)IBA 01/2021 - 01/2014
13	Peptide Receptors (Peptide Receptor)IBA 01/2021 - 01/2014
8	LigandsIBA 04/2024 - 02/2016
7	Biomarkers (Surrogate Marker)IBA 01/2024 - 01/2013
6	1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acidIBA 03/2024 - 04/2014
6	PSMA I&TIBA 12/2023 - 02/2020
5	Proteins (Proteins, Gene)FDA Link 05/2022 - 01/2013
4	RadiopharmaceuticalsIBA 05/2024 - 01/2015
4	Tyrosine (L-Tyrosine)FDA Link 01/2023 - 01/2013
4	Tyrosine Kinase InhibitorsIBA 01/2022 - 01/2018
4	Glucose (Dextrose)FDA LinkGeneric 04/2020 - 09/2016
4	Methionine (L-Methionine)FDA Link 08/2019 - 01/2013
4	Edotreotide (SMT 487)IBA 01/2019 - 04/2014
4	ChemokinesIBA 10/2018 - 01/2013
3	minigastrinIBA 03/2024 - 03/2023
3	IodineIBA 12/2023 - 04/2015
3	Mitotane (Lysodren)FDA Link 03/2022 - 03/2016
3	3-Iodobenzylguanidine (Iobenguane)IBA 12/2020 - 07/2019
3	CXC ChemokinesIBA 12/2020 - 01/2017
3	gallium 68 PSMA-11IBA 11/2020 - 06/2015
3	Bortezomib (Velcade)FDA Link 01/2020 - 04/2015
3	Amino Acids FDA Link 12/2019 - 01/2013
3	Norepinephrine (Noradrenaline)FDA LinkGeneric 02/2019 - 12/2017
2	Fatty Acids (Saturated Fatty Acids)IBA 01/2024 - 10/2018
2	Cholecystokinin B ReceptorIBA 11/2023 - 11/2023
2	AA amyloidosisIBA 01/2023 - 01/2022
2	4- (N- methylamino)- 4'- (2- (2- (2- fluoroethoxy)ethoxy)ethoxy)stilbeneIBA 01/2023 - 07/2019
2	Norepinephrine Plasma Membrane Transport Proteins (Norepinephrine Transporter)IBA 01/2022 - 01/2020
2	2- (3- (1- carboxy- 5- ((6- fluoropyridine- 3- carbonyl)amino)pentyl)ureido)pentanedioic acidIBA 01/2022 - 01/2020
2	Sorafenib (BAY 43-9006)FDA Link 10/2021 - 01/2020
2	Monoclonal AntibodiesIBA 01/2020 - 09/2016
2	Dexamethasone (Maxidex)FDA LinkGeneric 01/2020 - 09/2016
2	lutetium Lu 177 dotatateIBA 11/2019 - 01/2018
2	Dopamine Plasma Membrane Transport Proteins (Dopamine Transporter)IBA 10/2019 - 01/2015
2	ioflupaneIBA 10/2019 - 01/2019
2	Choline (Choline Chloride)IBA 08/2019 - 07/2016
2	1,2- di- (4- sulfamidophenyl)- 4- butylpyrazolidine- 3,5- dione (DSB)IBA 07/2019 - 02/2016
2	DNA (Deoxyribonucleic Acid)IBA 07/2019 - 02/2016
2	vandetanib (ZD6474)IBA 01/2019 - 01/2018
2	Cardiac MyosinsIBA 01/2019 - 12/2016
2	AcidsIBA 12/2018 - 09/2012
2	gallium Ga 68 dotatateIBA 01/2017 - 09/2012
1	Bombesin Receptors (Bombesin Receptor)IBA 04/2024
1	Eosine Yellowish-(YS) (Eosin)IBA 01/2024
1	Hematoxylin (Haematoxylon)IBA 01/2024
1	Prostate-Specific Antigen (Semenogelase)IBA 12/2023
1	Polyethylene Glycols (Polyethylene Glycol)FDA LinkGeneric 11/2023
1	cyclo(tyrosyl- arginyl- arginyl- 3- (2- naphthyl)alanyl- glycyl) (FC 131)IBA 11/2023
1	Fluorine-18IBA 03/2023
1	Chelating AgentsIBA 03/2023
1	Messenger RNA (mRNA)IBA 01/2023

Therapy/Procedure

53	Therapeutics 05/2024 - 01/2013
17	Precision Medicine 02/2024 - 01/2017
9	Castration 05/2024 - 01/2021
6	Drug Therapy (Chemotherapy) 05/2020 - 02/2016
4	Radiotherapy 05/2020 - 02/2016
4	Stem Cell Transplantation 01/2019 - 09/2014
3	Hematopoietic Stem Cell Transplantation 01/2023 - 01/2018
2	Thyroidectomy 03/2018 - 01/2015